Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145)

Org Biomol Chem. 2003 Aug 7;1(15):2626-9. doi: 10.1039/b306682g.

Abstract

The effects of Soto's 'beta-sheet breaker peptide' and its polymer on PrPSc formation in ScN2a cells were investigated. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the 'beta-sheet breaker peptide' is not specific and may not play a major role in the inhibition of PrPSc formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biopolymers / chemistry
  • Biopolymers / metabolism*
  • Mice
  • Molecular Sequence Data
  • Neuroblastoma / metabolism*
  • Neuroblastoma / pathology
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism*
  • Peptides / chemistry
  • Peptides / metabolism*
  • PrPSc Proteins / pathogenicity*
  • Prions / chemistry
  • Prions / metabolism*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Surface Plasmon Resonance
  • Tumor Cells, Cultured

Substances

  • Biopolymers
  • Peptide Fragments
  • Peptides
  • PrPSc Proteins
  • Prions