Abstract
Transgenic animal bioreactors represent a powerful tool to address the growing need for therapeutic recombinant proteins. The ability of transgenic animals to produce complex, biologically active recombinant proteins in an efficient and economic manner has stimulated a great deal of interest in this area. As a result, genetically modified animals of several species, expressing foreign proteins in various tissues, are currently being developed. However, the generation of transgenic animals is a cumbersome process and remains problematic in the application of this technology. The advantages and disadvantages of different transgenic systems in relation to other bioreactor systems are discussed.
MeSH terms
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Animals
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Animals, Genetically Modified / genetics*
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Animals, Genetically Modified / physiology
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Bioreactors / economics
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Blood Proteins / genetics
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Blood Proteins / metabolism
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Cells, Cultured
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Commerce / economics
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Commerce / legislation & jurisprudence
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Consumer Product Safety
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Environment
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Genetic Engineering / ethics
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Genetic Engineering / legislation & jurisprudence
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Genetic Engineering / methods
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Milk Proteins / genetics
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Milk Proteins / metabolism
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Ovum / physiology
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Patents as Topic / legislation & jurisprudence
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Recombinant Proteins / biosynthesis*
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Recombinant Proteins / economics
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Recombinant Proteins / genetics
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Semen / physiology
Substances
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Blood Proteins
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Milk Proteins
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Recombinant Proteins