[In situ production of interferon gamma and interleukin 6 by infiltrating cells from human kidney allografts in irreversible rejection. Modulation by cytokines]

P Merville; C Pouteil-Noble; J Wijdenes; L Potaux; J L Touraine; J Banchereau

[In situ production of interferon gamma and interleukin 6 by infiltrating cells from human kidney allografts in irreversible rejection. Modulation by cytokines]

Presse Med. 1992 Dec 2;21(41):1966-7.

[Article in French]

Authors

P Merville¹, C Pouteil-Noble, J Wijdenes, L Potaux, J L Touraine, J Banchereau

Affiliation

¹ Schering-Plough, Dardilly.

PMID: 1294954

Abstract

Using ELISPOT assays, we detected a significant number of cells secreting interferon-gamma and interleukin 6 among 8 irreversibly rejected kidney allografts compared with normal kidneys. Interleukin 2 increases the frequency of interferon-gamma producing cells and interleukin 4 decreases the frequency of both interferon-gamma and interleukin 6 producing cells.

Publication types

English Abstract

MeSH terms

Depression, Chemical
Graft Rejection / immunology*
Humans
Interferon-gamma / biosynthesis*
Interleukin-2 / pharmacology
Interleukin-4 / pharmacology
Interleukin-6 / biosynthesis*
Kidney / drug effects
Kidney / metabolism*
Kidney Transplantation / methods*
Stimulation, Chemical

Substances

Interleukin-2
Interleukin-6
Interleukin-4
Interferon-gamma