Potentiated antibodies against morphine: effects on biogenic amines and lipid peroxidation in chronically morphinized rats

Bull Exp Biol Med. 2003 Jan:135 Suppl 7:134-6. doi: 10.1023/a:1024784225870.

Abstract

The efficiency of potentiated antibodies against morphine was studied on the model of chronic morphine intoxication. Test antibodies stimulated catecholamine metabolism in the hypothalamus (i.e., prevented initiation of catecholamine- and histaminergic peripheral reactions) and normalized lipid peroxidation.

MeSH terms

  • Animals
  • Antibodies / pharmacology*
  • Biogenic Amines / metabolism*
  • Catecholamines / metabolism
  • Hypothalamus / metabolism
  • Lipid Peroxidation / drug effects*
  • Morphine / antagonists & inhibitors*
  • Morphine / immunology
  • Morphine Dependence
  • Rats

Substances

  • Antibodies
  • Biogenic Amines
  • Catecholamines
  • Morphine