Abstract
The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / pharmacology*
-
Drug Evaluation, Preclinical / methods
-
Haemophilus influenzae / drug effects*
-
Haemophilus influenzae / growth & development
-
Humans
-
Microbial Sensitivity Tests / methods
-
Oxadiazoles / chemical synthesis
-
Oxadiazoles / pharmacology*
-
Pyrazines / chemical synthesis
-
Pyrazines / pharmacology*
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Oxadiazoles
-
Pyrazines