Abstract
A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / toxicity*
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Cell Line
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Cell Line, Tumor
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Glucose / chemical synthesis
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Glucose / toxicity
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Humans
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Ribavirin / analogs & derivatives*
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Ribavirin / chemical synthesis*
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Ribavirin / toxicity*
Substances
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Antineoplastic Agents
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Ribavirin
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Glucose
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tiazofurin