Abstract
A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Benzimidazoles / chemistry*
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Benzimidazoles / pharmacology
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Enterococcus / drug effects
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Enterococcus / growth & development
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Microbial Sensitivity Tests / methods
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Piperidines / chemistry*
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Piperidines / pharmacology
Substances
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Anti-Bacterial Agents
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Benzimidazoles
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Piperidines