Abstract
Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Transport / drug effects
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Biological Transport / physiology
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Dimerization
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Polyamines / chemistry*
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Polyamines / metabolism
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Polyamines / pharmacology
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Putrescine / chemistry*
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Putrescine / metabolism
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Putrescine / pharmacology
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Spermidine / antagonists & inhibitors*
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Spermidine / metabolism
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Xylenes / chemistry*
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Xylenes / metabolism
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Xylenes / pharmacology
Substances
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Polyamines
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Xylenes
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Spermidine
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Putrescine