Immune reconstitution inflammatory syndrome mimicking relapse of AIDS related lymphoma in patients with HIV 1 infection

Leuk Lymphoma. 2003 Aug;44(8):1417-9. doi: 10.1080/1042819031000083280.

Abstract

People with HIV infection who commence highly active antiretroviral therapy (HAART) occasionally develop reactivation of subclinical infection. This clinical entity is termed immune reconstitution inflammatory syndrome (IRIS) and is defined as a paradoxical deterioration in clinical status as a result of recovery of the immune system during HAART. We present three cases of IRIS following a diagnosis of AIDS related non-Hodgkin's lymphoma that resembled lymphoma relapse.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects
  • Bacterial Infections / chemically induced
  • Bacterial Infections / diagnosis*
  • Bacterial Infections / pathology
  • Diagnosis, Differential
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • Humans
  • Immune System / microbiology*
  • Immune System / pathology
  • Immune System / physiology
  • Inflammation / diagnosis*
  • Inflammation / microbiology
  • Lymphoma, AIDS-Related / diagnosis*
  • Male
  • Mycobacterium avium-intracellulare Infection / chemically induced
  • Mycobacterium avium-intracellulare Infection / diagnosis
  • Mycobacterium avium-intracellulare Infection / pathology
  • Neck / microbiology
  • Neck / pathology
  • Recurrence
  • Regeneration
  • Syndrome