Abstract
In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activate the critical downstream targets, including selected subsets of the major HOX genes.
MeSH terms
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Animals
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Dimerization
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Gene Expression Regulation, Neoplastic
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Histone-Lysine N-Methyltransferase
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Homeodomain Proteins
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Humans
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Leukemia / genetics
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Leukemia / metabolism*
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Leukemia / pathology
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Mice
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Myeloid-Lymphoid Leukemia Protein
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Protein Structure, Tertiary
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Proto-Oncogenes*
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Recombinant Fusion Proteins / chemistry*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism*
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Trans-Activators / genetics
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Transcription Factors*
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Transcriptional Activation
Substances
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DNA-Binding Proteins
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Homeodomain Proteins
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KMT2A protein, human
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Recombinant Fusion Proteins
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Trans-Activators
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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HoxA protein
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Histone-Lysine N-Methyltransferase
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Kmt2a protein, mouse