Takayasu's disease affects the aorta and its major branches including coronary arteries, some of which may require coronary artery bypass grafting (CABG). However, calcification of the aorta affected by Takayasu's disease often makes proximal anastomosis of a vein graft very difficult. In addition, since the major branches of the aortic arch are also frequently affected by it, the internal mammary arteries are unsuitable for use in CABG. We report a 60-year-old woman with stenosis of the left main coronary artery and heavy aortic calcification caused by Takayasu's disease whose severe angina was successfully relieved by off-pump CABG using mechanical aortic connectors for proximal vein graft anastomoses.