Fibrous hamartoma of infancy. A study of eight cases with immunohistochemical and electron microscopical findings

Pathol Res Pract. 1992 Dec;188(8):1049-53. doi: 10.1016/S0344-0338(11)81250-1.

Abstract

Eight cases of fibrous hamartomas of infancy are presented. Actin positivity and desmin negativity in collagen forming spindle-shaped cells and electron microscopical findings point to the myofibroblastic nature of this entity. "Dark cells" which spread regularly in all but one of our tumors were immunohistochemically determined to be a mixture of B and T cell lymphocytes. Their selective location and possible role are discussed.

MeSH terms

  • Actins / analysis
  • Child, Preschool
  • Female
  • Hamartoma / chemistry
  • Hamartoma / pathology*
  • Hamartoma / ultrastructure
  • Humans
  • Infant
  • Male
  • Microscopy, Electron
  • S100 Proteins / analysis
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / ultrastructure

Substances

  • Actins
  • S100 Proteins