Immunosuppression without prophylactic antilymphocyte preparations

Clin Transpl. 1992:237-48.

Abstract

1. Triple-drug immunosuppression following third party transfusion can result in graft survival equal to protocols that employ prophylactic antilymphocyte preparations. 2. T1/2 was statistically improved in cadaveric and living-related donor grafts in the CsA era. 3. Patients 65 years and older had an excessive death rate. Younger groups were admixed. Extreme youth was not a risk factor. 4. Black recipients had excessive late graft loss. 5. Diabetic recipients had only a slight decline in graft and patient survival rates. 6. First and multiple graft recipients had similar transplant survival rates. 7. Delayed graft function remains costly in this immunosuppressive scheme.

MeSH terms

  • Academic Medical Centers
  • Adult
  • Aged
  • Antilymphocyte Serum / therapeutic use
  • Cadaver
  • Cyclosporine / therapeutic use
  • Florida / epidemiology
  • Graft Survival
  • Humans
  • Immunosuppression Therapy / methods*
  • Kidney Transplantation / immunology*
  • Kidney Transplantation / methods*
  • Kidney Transplantation / mortality
  • Middle Aged
  • Risk Factors
  • Survival Rate
  • Tissue Donors

Substances

  • Antilymphocyte Serum
  • Cyclosporine