Abstract
Chromatographic and magnetic resonance spectroscopic measurements of thiol reduction-oxidation state in chemically constructed samples show close analytical agreement. This result, coupled with the synthesis of new probe molecules allowing greater sensitivity and lower toxicity, supports the development of an NMR method for non-invasive thiol redox measurement, an important variable in the response of tumors to radiation and chemotherapy.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amifostine / analogs & derivatives*
-
Carbon Radioisotopes
-
Glutathione / analogs & derivatives
-
Glutathione Disulfide
-
Indicators and Reagents
-
Magnetic Resonance Spectroscopy
-
Oxidation-Reduction
-
Radiation-Protective Agents*
Substances
-
Carbon Radioisotopes
-
Indicators and Reagents
-
Radiation-Protective Agents
-
S-2-(3-methylaminopropylamino)ethylphosphorothioic acid
-
Glutathione
-
Amifostine
-
Glutathione Disulfide