The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase

Gene. 1992 Mar 15;112(2):213-8. doi: 10.1016/0378-1119(92)90378-3.

Abstract

We describe the cloning of a multifunctional folic acid synthesis (fas) gene from Pneumocystis carinii. The nucleotide sequence contains an open reading frame interrupted by three introns, that encodes a protein of 740 amino acids with an Mr of 97,278. The predicted Fas protein has homology to two enzyme domains, dihydropteroate synthase and 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, both of which are involved in folate synthesis, and at least one other region of unknown function.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • Dihydropteroate Synthase / genetics*
  • Diphosphotransferases*
  • Folic Acid / biosynthesis*
  • Genes, Fungal / genetics*
  • Molecular Sequence Data
  • Phosphotransferases / genetics*
  • Pneumocystis / enzymology*
  • Pneumocystis / genetics

Substances

  • Folic Acid
  • Dihydropteroate Synthase
  • Phosphotransferases
  • Diphosphotransferases
  • 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Associated data

  • GENBANK/M62416
  • GENBANK/M62417
  • GENBANK/M63477
  • GENBANK/M63478
  • GENBANK/M63479
  • GENBANK/M86602
  • GENBANK/S40001
  • GENBANK/S40008
  • GENBANK/S40009
  • GENBANK/S40010