Abstract
Previous studies have implicated the glycolipid receptor for the Escherichia coli-derived verotoxin, globotriaosylceramide (Gb3; Gal alpha 1-4Gal beta 1-4Glc-ceramide), in the mechanism of alpha 2 interferon signal transduction. Comparison of the amino acid sequence of the human alpha 2 interferon receptor with that of the B (receptor-binding)-subunit of verotoxin shows three regions of similarity which may provide a structural basis for alpha 2-interferon-receptor/Gb3 interaction.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Toxins / genetics*
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Bacterial Toxins / metabolism
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Carbohydrate Sequence
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Glycolipids / genetics*
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Glycolipids / metabolism*
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Humans
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Macromolecular Substances
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Molecular Sequence Data
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism
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Receptors, Immunologic / genetics*
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Receptors, Immunologic / metabolism
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Receptors, Interferon
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Sequence Homology, Nucleic Acid
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Shiga Toxin 1
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Trihexosylceramides / metabolism
Substances
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Bacterial Toxins
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Glycolipids
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Macromolecular Substances
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Receptors, Cell Surface
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Receptors, Immunologic
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Receptors, Interferon
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Shiga Toxin 1
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Shiga-like toxin receptor
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Trihexosylceramides
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globotriaosylceramide