Abstract
Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) microgram/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less than or equal to 2.0 micrograms/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin / pharmacology*
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Amoxicillin-Potassium Clavulanate Combination
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents*
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Clavulanic Acids / pharmacology*
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Clindamycin / pharmacology*
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Drug Resistance, Microbial
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Drug Therapy, Combination / pharmacology*
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Fluoroquinolones*
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Gram-Negative Anaerobic Bacteria / drug effects*
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In Vitro Techniques
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Lactams*
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Microbial Sensitivity Tests
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Quinolones / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Clavulanic Acids
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Fluoroquinolones
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Lactams
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Quinolones
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C6-(N1-methyl-1,2,3-trazolylmethylene)penem
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temafloxacin
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Clindamycin
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin