Regulation of TCR alpha and beta gene allelic exclusion during T-cell development

M Malissen; J Trucy; E Jouvin-Marche; P A Cazenave; R Scollay; B Malissen

doi:10.1016/0167-5699(92)90044-8

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development

Immunol Today. 1992 Aug;13(8):315-22. doi: 10.1016/0167-5699(92)90044-8.

Authors

M Malissen¹, J Trucy, E Jouvin-Marche, P A Cazenave, R Scollay, B Malissen

Affiliation

¹ Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.

PMID: 1324691
DOI: 10.1016/0167-5699(92)90044-8

Abstract

Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.

Publication types

Review

MeSH terms

Alleles
Animals
Clone Cells
DNA Nucleotidyltransferases / genetics
Gene Expression Regulation*
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor / genetics
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / genetics
Mice
Mice, Transgenic
Receptors, Antigen, T-Cell, alpha-beta / genetics*
T-Lymphocytes / immunology*
VDJ Recombinases

Substances

Receptors, Antigen, T-Cell, alpha-beta
DNA Nucleotidyltransferases
VDJ Recombinases