Abstract
The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cycloleucine / analogs & derivatives
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Cycloleucine / pharmacology
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Hippocampus / drug effects
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Hippocampus / physiology
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In Vitro Techniques
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Rats
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Receptors, Glutamate
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Synapses / drug effects
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Synapses / physiology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology*
Substances
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Receptors, Glutamate
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Receptors, Neurotransmitter
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Cycloleucine
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1-amino-1,3-dicarboxycyclopentane