Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone

A Chiarini; A Rampa; A Bisi; R Budriesi; P Valenti

Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone

Arzneimittelforschung. 1992 Jun;42(6):797-801.

Authors

A Chiarini¹, A Rampa, A Bisi, R Budriesi, P Valenti

Affiliation

¹ Department of Pharmaceutical Sciences, University of Bologna, Italy.

PMID: 1329778

Abstract

A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta, Thoracic / drug effects
Calcium Channels / drug effects*
Depression, Chemical
Dihydropyridines / pharmacology*
Female
Guinea Pigs
Heart Rate / drug effects*
In Vitro Techniques
Ligands
Male
Muscle Contraction / drug effects
Myocardial Contraction / drug effects*
Stimulation, Chemical
Xanthenes / pharmacology*

Substances

Calcium Channels
Dihydropyridines
Ligands
Xanthenes