Abstract
The effect of norepinephrine and epinephrine on the activity of low Km GTPase was studied in striata from young and old rats. Results showed that the amines stimulated the low Km GTPase activity of both young and old animals in a concentration-dependent manner. There was no differential effect of the amines as a function of age, but the stimulated low Km GTPase activity was significantly lower in the aged tissue.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aging / metabolism*
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Animals
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Corpus Striatum / drug effects*
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Corpus Striatum / enzymology
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Epinephrine / pharmacology*
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GTP Phosphohydrolases / metabolism*
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Kinetics
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Norepinephrine / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Adrenergic, alpha / drug effects*
Substances
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Receptors, Adrenergic, alpha
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GTP Phosphohydrolases
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Norepinephrine
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Epinephrine