Abstract
Squalene inhibited the effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), such as increased 32Pi incorporation into phospholipids of HeLa cell membrane, induction of Epstein-Barr-virus early antigen in Raji cell and induction of ornithine decarboxylase in mouse skin. Squalene also markedly suppressed the promoting activity of TPA on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anticarcinogenic Agents / pharmacology*
-
Antigens, Viral / drug effects
-
Cell Line
-
Enzyme Induction / drug effects
-
HeLa Cells
-
Herpesvirus 4, Human / drug effects
-
Herpesvirus 4, Human / immunology
-
Humans
-
Membrane Lipids / metabolism
-
Mice
-
Ornithine Decarboxylase / drug effects
-
Phospholipids / metabolism
-
Skin Neoplasms / etiology
-
Skin Neoplasms / metabolism
-
Skin Neoplasms / prevention & control*
-
Squalene / pharmacology*
-
Tetradecanoylphorbol Acetate / analogs & derivatives
-
Virus Activation / drug effects
Substances
-
Anticarcinogenic Agents
-
Antigens, Viral
-
Epstein-Barr virus early antigen
-
Membrane Lipids
-
Phospholipids
-
12-O-tetradeca-2,4,6,8-tetranoylphorbol-13-acetate
-
Squalene
-
Ornithine Decarboxylase
-
Tetradecanoylphorbol Acetate