Abstract
Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups. In Caucasians HPA-1a is the antigen most frequently implicated. In Japan, NAIT due to anti-HPA-4b antibody has already been described, but this is the first case to be reported in Caucasians.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, Human Platelet / genetics
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Antigens, Human Platelet / immunology*
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Female
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Gene Frequency
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Histocompatibility Testing
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Humans
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Immunity, Maternally-Acquired*
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Infant, Newborn
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Isoantibodies / immunology*
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Male
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Pedigree
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Platelet Membrane Glycoproteins / genetics
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Platelet Membrane Glycoproteins / immunology*
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Pregnancy
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Thrombocytopenia / congenital*
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Thrombocytopenia / genetics
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Thrombocytopenia / immunology
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White People / genetics
Substances
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4b alloantigen, human
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Antigens, Human Platelet
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Isoantibodies
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Platelet Membrane Glycoproteins