Alkaline-encrusted cystitis (AEC) is a chronic inflammation of the bladder related to the gram-positive bacillus Corynebacterium Group D2. This germ is often resistant to many antibiotics and is particularly difficult to eradicate in the particular setting of AEC. The authors report two observations of AEC treated with the glycopeptid antibiotic teicoplanin, which led to permanent cure of AEC.