Use of MAC-ELISA for evaluation of yellow fever vaccination

Rev Inst Med Trop Sao Paulo. 1992 Sep-Oct;34(5):447-50. doi: 10.1590/s0036-46651992000500012.

Abstract

An evaluation of the IgM antibody immune response against yellow fever using strain 17D was carried out by MAC-ELISA and PRNT. The results showed an agreement of 97% between both tests and the authors conclude that MAC-ELISA can be used as a specific and sensitive assay to replace the PRNT for detecting yellow fever antibodies in human sera, after vaccination programs.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies, Viral / blood*
  • Dengue / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Evaluation Studies as Topic
  • Hemolytic Plaque Technique
  • Humans
  • Neutralization Tests
  • Viral Vaccines / immunology*
  • Yellow Fever / immunology
  • Yellow fever virus / immunology*

Substances

  • Antibodies, Viral
  • Viral Vaccines