Synthesis and binding of peptide T and aminoacyl derivatives to CD4+ lymphocytes

L H van den Heever; J H Jordaan; I A Dubery

doi:10.1016/0020-711x(92)90267-5

Synthesis and binding of peptide T and aminoacyl derivatives to CD4+ lymphocytes

Int J Biochem. 1992 Feb;24(2):337-9. doi: 10.1016/0020-711x(92)90267-5.

Authors

L H van den Heever¹, J H Jordaan, I A Dubery

Affiliation

¹ Department of Biochemistry, Delta G Scientific, Johannesburg, South Africa.

PMID: 1346383
DOI: 10.1016/0020-711x(92)90267-5

Abstract

1. Peptide T and four other aminoacyl derivatives of this octapeptide were synthesized on solid phase support using the Boc and Fmoc procedures. 2. The octapeptides were modified by chloroacetylation and radiolabelled by halogen exchange with 125I. 3. Purified and crude extracts of lymphocytes were used to determine the binding of the octapeptides at different concentrations.

MeSH terms

Amino Acid Sequence
Biological Transport
CD4-Positive T-Lymphocytes / metabolism*
Humans
Molecular Sequence Data
Peptide T / analogs & derivatives
Peptide T / chemical synthesis
Peptide T / metabolism*

Substances

Peptide T