Fatal neutropenic enterocolitis associated with sulphasalazine therapy for rheumatoid arthritis

K Chakravarty; D G Scott; B G McCann

doi:10.1093/rheumatology/31.5.351

Fatal neutropenic enterocolitis associated with sulphasalazine therapy for rheumatoid arthritis

Br J Rheumatol. 1992 May;31(5):351-3. doi: 10.1093/rheumatology/31.5.351.

Authors

K Chakravarty¹, D G Scott, B G McCann

Affiliation

¹ Department of Rheumatology, Norfolk and Norwich Hospital.

PMID: 1349846
DOI: 10.1093/rheumatology/31.5.351

Abstract

Neutropenia is a recognized complication of sulphasalazine therapy in patients with rheumatoid arthritis. It is usually mild, transient and rarely associated with serious sequelae. We describe a patient with rheumatoid arthritis who developed fatal neutropenic enterocolitis complicated by tracheo-oesophageal fistula following treatment with sulphasalazine.

Publication types

Case Reports

MeSH terms

Aged
Arthritis, Rheumatoid / drug therapy*
Enterocolitis / chemically induced*
Enterocolitis / complications
Humans
Male
Neutropenia / chemically induced*
Neutropenia / complications
Sulfasalazine / adverse effects*
Sulfasalazine / therapeutic use*

Substances

Sulfasalazine