A rare FokI RFLP in the human dopamine D2 receptor gene (DRD2)

Hum Genet. 1992 May;89(3):360. doi: 10.1007/BF00220561.

Abstract

A new biallelic polymorphism for FokI restriction enzyme due to C----T transition in the fourth intron of human DRD2 is described. It must be a usefull marker of this candidate gene for several mental disorders.

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 11* / metabolism
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Gene Frequency / genetics
  • Genetic Markers / genetics
  • Humans
  • Introns / genetics
  • Molecular Sequence Data
  • Mutation / genetics
  • Oligodeoxyribonucleotides / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length*
  • Receptors, Dopamine / genetics*
  • Receptors, Dopamine D2
  • White People / genetics

Substances

  • Genetic Markers
  • Oligodeoxyribonucleotides
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific