[Shedding of soluble intercellular adhesion molecule 1 (ICAM-1) from melanoma cells and the effect on cellular cytotoxicity]

J C Becker; R Dummer; R E Schmidt; G Burg; A A Hartmann

[Shedding of soluble intercellular adhesion molecule 1 (ICAM-1) from melanoma cells and the effect on cellular cytotoxicity]

Immun Infekt. 1992 Apr;20(2):62-3.

[Article in German]

Authors

J C Becker¹, R Dummer, R E Schmidt, G Burg, A A Hartmann

Affiliation

¹ Universitäts-Hautklinik Würzburg.

PMID: 1351873

Abstract

ICAM-1-mediated cell-cell adhesion is essential for various immunologic functions, including non-MHC-restricted cytotoxicity. Shedding of ICAM-1 occurred after stimulation of melanoma cells with TNF alpha and IFN gamma. Soluble forms of ICAM-1 inhibited the conjugate formation of NK clones with K562 and of LAK cells with melanoma cells. Furthermore, the non-MHC-restricted cytotoxicity mediated by NK clones or LAK cells could be abrogated by soluble ICAM-1.

Publication types

English Abstract

MeSH terms

Cell Adhesion Molecules / chemistry
Cell Adhesion Molecules / metabolism*
Cell Adhesion*
Cytotoxicity, Immunologic*
Humans
Immunity, Cellular*
Intercellular Adhesion Molecule-1
Interferon-gamma / pharmacology
Melanoma / immunology
Melanoma / metabolism*
Solubility
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / pharmacology

Substances

Cell Adhesion Molecules
Tumor Necrosis Factor-alpha
Intercellular Adhesion Molecule-1
Interferon-gamma