Abstract
Cyclophosphamide is used both in the treatment of malignant and non-malignant diseases. Urinary neoplasms secondary to its use have been described. We discuss the case of a patient with panarteritis nodosa treated with cyclophosphamide during 63 months, with a total dose of 210 grams, and that showed a bladder neoplasm 8 years after beginning of the treatment. In patients receiving a total dose of cyclophosphamide over 85 grams, a follow-up of ten years minimum should be performed aimed to the early detection of secondary neoplasms.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Aged
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Bone Neoplasms / secondary
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / adverse effects*
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Humans
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Lung Neoplasms / secondary
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Male
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Neoplasm Recurrence, Local / chemically induced*
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Neoplasm Recurrence, Local / surgery
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Papilloma / chemically induced*
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Papilloma / surgery
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Polyarteritis Nodosa / complications*
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Polyarteritis Nodosa / drug therapy
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Time Factors
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Urinary Bladder Neoplasms / chemically induced*
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Urinary Bladder Neoplasms / surgery
Substances
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Adrenal Cortex Hormones
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Cyclophosphamide