We report the case of a 42 year-old man, with a history of alcohol and tobacco abuse, who was referred for suspicion of carcinoma of the head of pancreas. Pancreatoduodenectomy was performed. Histological study demonstrated obstructive benign adenomyoma of the distal common bile duct associated with villous papillomatosis of the pancreatic ducts and patchy lesions of chronic pancreatitis. Two years later, the patient was completely asymptomatic, but the risk of malignant transformation of villous papillomatosis requires periodic examination of the remaining pancreas and biliary tract.