Radiographic, haematological, and biochemical findings in a fetus with Caffey disease

Prenat Diagn. 1992 Aug;12(8):637-41. doi: 10.1002/pd.1970120803.

Abstract

An early case of prenatal Caffey disease is reported. Ultrasound examination performed at 20 weeks showed major angulations of long bones, but both ultrasound scan and X-rays failed to make the differential diagnosis between Caffey disease and lethal osteogenesis imperfecta. A cordocentesis allowed us to find important biological abnormalities. The pregnancy was terminated after the rapid development of hydrops fetalis. The definitive diagnosis of Caffey disease was obtained by special X-ray and pathological study.

Publication types

  • Case Reports

MeSH terms

  • 5'-Nucleotidase / blood
  • Abortion, Therapeutic
  • Adult
  • Blood Cell Count
  • C-Reactive Protein / metabolism
  • Cordocentesis
  • Diagnostic Errors
  • Female
  • Humans
  • Hydrops Fetalis / complications
  • Hyperostosis, Cortical, Congenital / blood
  • Hyperostosis, Cortical, Congenital / complications
  • Hyperostosis, Cortical, Congenital / diagnosis*
  • Hyperostosis, Cortical, Congenital / diagnostic imaging
  • Immunoglobulin M / analysis
  • Osteogenesis Imperfecta / diagnosis
  • Pregnancy
  • Prenatal Diagnosis*
  • Radiography
  • gamma-Glutamyltransferase / blood

Substances

  • Immunoglobulin M
  • C-Reactive Protein
  • gamma-Glutamyltransferase
  • 5'-Nucleotidase