Abstract
Bioactivity-guided fractionation of a CHCl3 extract of the soft coral Lobophytum michaelae afforded a new cytotoxic cembranolide, lobomichaolide (1), and a known cytotoxic cembranolide, crassolide (2). The structure of 1 was determined by spectral and X-ray crystallographic analysis.
MeSH terms
-
Animals
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification*
-
Antineoplastic Agents / pharmacology
-
Cnidaria / chemistry*
-
Cnidaria / physiology
-
Cytotoxins / chemistry
-
Cytotoxins / isolation & purification*
-
Cytotoxins / pharmacology
-
Diterpenes / chemistry
-
Diterpenes / isolation & purification*
-
Diterpenes / pharmacology
-
HeLa Cells
-
Humans
-
KB Cells
-
Leukemia P388 / drug therapy
-
Tumor Cells, Cultured
-
X-Ray Diffraction
Substances
-
Antineoplastic Agents
-
Cytotoxins
-
Diterpenes
-
lobomichaolide
-
crassolide