Proline-specific aminopeptidases: potential role in bradykinin degradation

G Vanhoof; I de Meester; D Hendriks; F Goossens; M van Sande; S Scharpé; A Yaron

Proline-specific aminopeptidases: potential role in bradykinin degradation

Agents Actions Suppl. 1992:38 ( Pt 2):120-7.

Authors

G Vanhoof¹, I de Meester, D Hendriks, F Goossens, M van Sande, S Scharpé, A Yaron

Affiliation

¹ Laboratory of Medical Biochemistry, University of Antwerp, Wilrijk, Belgium.

PMID: 1361094

Abstract

The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5). Additional evidence is provided for the hypothesis that these proline-specific aminopeptidases play an essential role in the degradation of peptides containing an N-terminal Xaa-Pro sequence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminopeptidases / metabolism*
Blood Platelets / enzymology
Bradykinin / analogs & derivatives*
Bradykinin / metabolism*
Dipeptidyl Peptidase 4
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism*
Humans
Kinetics

Substances

Aminopeptidases
prolyl aminopeptidase
X-Pro aminopeptidase
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Dipeptidyl Peptidase 4
Bradykinin