Major histocompatibility complex located complement C4 and steroid 21-hydroxylase gene rearrangements in couples with recurrent spontaneous abortions

T Laitinen; M L Lokki; J Partanen; M Tulppala; O Ylikorkala; S Koskimies

doi:10.1111/j.1744-313x.1992.tb00084.x

Major histocompatibility complex located complement C4 and steroid 21-hydroxylase gene rearrangements in couples with recurrent spontaneous abortions

Eur J Immunogenet. 1992 Dec;19(6):413-8. doi: 10.1111/j.1744-313x.1992.tb00084.x.

Authors

T Laitinen¹, M L Lokki, J Partanen, M Tulppala, O Ylikorkala, S Koskimies

Affiliation

¹ Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Helsinki.

PMID: 1362078
DOI: 10.1111/j.1744-313x.1992.tb00084.x

Abstract

Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21-hydroxylase (21OH) genes, which form various deletion and duplication units, were studied by TaqI Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found in the RSA couples did not differ from those in the controls.

MeSH terms

Abortion, Habitual / enzymology
Abortion, Habitual / genetics*
Abortion, Habitual / immunology
Complement C4 / genetics*
Female
Gene Deletion
Gene Rearrangement*
Humans
Major Histocompatibility Complex
Male
Multigene Family
Mutation
Polymorphism, Restriction Fragment Length
Pregnancy
Steroid 21-Hydroxylase / genetics*

Substances

Complement C4
Steroid 21-Hydroxylase