Antagonism of medetomidine sedation by atipamezole in pigs

J Vet Med Sci. 1992 Dec;54(6):1237-40. doi: 10.1292/jvms.54.1237.

Abstract

The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 micrograms/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 micrograms/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 micrograms/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adrenergic alpha-Agonists / antagonists & inhibitors*
  • Adrenergic alpha-Antagonists / pharmacology*
  • Animals
  • Body Temperature / drug effects
  • Heart Rate / drug effects
  • Hypnotics and Sedatives / antagonists & inhibitors*
  • Imidazoles / antagonists & inhibitors*
  • Imidazoles / pharmacology*
  • Male
  • Medetomidine
  • Swine* / physiology

Substances

  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Hypnotics and Sedatives
  • Imidazoles
  • atipamezole
  • Medetomidine