Expression of aminopeptidase N and neutral endopeptidase on the endometrial stromal cells in endometriosis and adenomyosis

K Imai; H Kanzaki; H Fujiwara; M Kariya; N Okamoto; K Takakura; M Maeda; T Mori

doi:10.1093/oxfordjournals.humrep.a137849

Expression of aminopeptidase N and neutral endopeptidase on the endometrial stromal cells in endometriosis and adenomyosis

Hum Reprod. 1992 Oct;7(9):1326-8. doi: 10.1093/oxfordjournals.humrep.a137849.

Authors

K Imai¹, H Kanzaki, H Fujiwara, M Kariya, N Okamoto, K Takakura, M Maeda, T Mori

Affiliation

¹ Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.

PMID: 1362204
DOI: 10.1093/oxfordjournals.humrep.a137849

Abstract

Indirect immunofluorescence staining revealed that endometrial stromal cells (ESC) in the ectopic endometrium of patients with endometriosis or adenomyosis expressed aminopeptidase N/cluster of differentiation (CD) 13 antigen and neutral endopeptidase/CD10 antigen, both of which are expressed on ESC in the normal endometrium throughout the menstrual cycle. Thus, ESC in the ectopic endometrium resembled ESC in the normal endometrium not only morphologically but also antigenically. Both peptidase antigens may be useful markers for the histological diagnosis of endometriosis and adenomyosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aminopeptidases / biosynthesis*
Antigens, CD / biosynthesis
Antigens, Differentiation, Myelomonocytic / biosynthesis
Biomarkers, Tumor / biosynthesis
CD13 Antigens
Endometriosis / metabolism*
Endometrium / cytology*
Female
Fluorescent Antibody Technique
Humans
Middle Aged
Neprilysin / biosynthesis*
Ovarian Neoplasms / metabolism*
Peritoneal Neoplasms / metabolism*
Stromal Cells / metabolism

Substances

Antigens, CD
Antigens, Differentiation, Myelomonocytic
Biomarkers, Tumor
Aminopeptidases
CD13 Antigens
Neprilysin