Abstract
Two series of compounds, 8-methoxy- and p-dimethoxy derivatives of 1-aminoethylhetero-tetralins, I, were evaluated for D-2, 5-HT1 and 5-HT2 receptors affinity. No significant serotoninergic affinity was observed, whereas p-dimethoxy-derivatives 7b e 11b showed a moderate D-2 affinity.
MeSH terms
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Animals
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Binding, Competitive / drug effects
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Brain / drug effects
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Brain / metabolism
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Dopamine Agents / chemical synthesis*
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Dopamine Agents / pharmacology
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In Vitro Techniques
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Rats
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Receptors, Dopamine D2 / drug effects
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Serotonin Receptor Agonists / chemical synthesis*
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Serotonin Receptor Agonists / pharmacology
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Tetrahydronaphthalenes / chemical synthesis*
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Tetrahydronaphthalenes / pharmacology
Substances
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Dopamine Agents
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Receptors, Dopamine D2
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Serotonin Receptor Agonists
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Tetrahydronaphthalenes