Abstract
The effect of 5-hydroxytryptamine and renzapride was studied on the peristaltic reflex elicited in vitro in the guinea-pig ileum. Both agents evoked the reflex at subthreshold intraluminal pressures (50% of threshold) and were blocked by ICS 205-930 (3 microM), but not ondansetron (5 microM). This novel finding suggests strongly that the prokinetic action of renzapride and gut motility stimulating action of 5-hydroxytryptamine are mediated via agonism at the putative 5-HT4 receptor.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Benzamides / pharmacology*
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Bridged Bicyclo Compounds / pharmacology*
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Bridged Bicyclo Compounds, Heterocyclic*
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Guinea Pigs
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In Vitro Techniques
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Indoles / pharmacology
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Male
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Peristalsis / drug effects*
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / physiology
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Serotonin / pharmacology*
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Tropisetron
Substances
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Benzamides
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Bridged Bicyclo Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Indoles
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Receptors, Serotonin
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Serotonin
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Tropisetron
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renzapride