Abstract
THE CONTEXT: The demonstration of the efficacy of oral anticoagulants in the secondary prevention of ischemic stroke represents a major progress in medicine in the last twenty years. Efficacy in fact depends on the causes and this determines the indications. ADMITTED AND DEMONSTRATED INDICATIONS: Cardiac arrhythmia due to atrial fibrillation and the existence of mechanical prosthetic valves are the only two indications that have been demonstrated with sufficient proof. ADMITTED NON-DEMONSTRATED INDICATIONS: These are basically the dissection of cervical arteries, aortal cross atheroma, vascular cerebral accidents within the context of antiphospholipid antibody syndromes. POSSIBLE INDICATIONS: There are three: stenosis of the intra-cranial arteries, patent foramen ovale with atrial septum aneurysm and the basilar dolichoectasia trunks. NON-DEMONSTRATED SUPERIORITY: In atherosclerosis-induced cerebral ischemic accidents.
Publication types
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Comparative Study
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English Abstract
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Review
MeSH terms
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Anticoagulants / administration & dosage
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Anticoagulants / therapeutic use*
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Antiphospholipid Syndrome / complications
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Arteriosclerosis / complications
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Aspirin / administration & dosage
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Aspirin / therapeutic use
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Atrial Fibrillation / complications
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Cardiovascular Diseases / complications
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Clinical Trials as Topic
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Drug Therapy, Combination
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Fibrinolytic Agents / administration & dosage
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Fibrinolytic Agents / therapeutic use
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Heart Valve Prosthesis
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Humans
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Intracranial Arterial Diseases / complications
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Platelet Aggregation Inhibitors / administration & dosage
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Platelet Aggregation Inhibitors / therapeutic use
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Primary Prevention
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Retrospective Studies
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Risk
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Risk Factors
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Stroke / prevention & control*
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Time Factors
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Warfarin / administration & dosage
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Warfarin / therapeutic use
Substances
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Anticoagulants
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Fibrinolytic Agents
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Platelet Aggregation Inhibitors
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Warfarin
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Aspirin