An investigation of the biological effect of structural modifications of isothiosemicarbazones and their cyclic analogues

Farmaco. 2003 Sep;58(9):951-9. doi: 10.1016/S0014-827X(03)00154-X.

Abstract

Several arylideneisothiosemicarbazones and arylidenehydrazothiazoles have been synthesised to obtain new antimicrobial agents. Their activity against both bacteria and fungi has been tested and some interesting informations about their biological activity have been obtained.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Drug Design
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Structure-Activity Relationship
  • Thiosemicarbazones / chemistry
  • Thiosemicarbazones / pharmacology*
  • Yeasts / drug effects

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Thiosemicarbazones