p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells

S J van den Heuvel; S I The; B Klein; A G Jochemsen; A Zantema; A J van der Eb

doi:10.1128/JVI.66.1.591-595.1992

p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells

J Virol. 1992 Jan;66(1):591-5. doi: 10.1128/JVI.66.1.591-595.1992.

Authors

S J van den Heuvel¹, S I The, B Klein, A G Jochemsen, A Zantema, A J van der Eb

Affiliation

¹ Laboratory of Molecular Carcinogenesis, Sylvius Laboratory, University of Leiden, The Netherlands.

Abstract

A panel of primary human cells and virus-transformed derivatives were tested for events that coincide with immortalization. In all primary and precrisis cells, two proteins of 92 and 150 kDa that shared an epitope with p53 were found; in most of their immortalized derivatives, however, they were absent. Expression of these proteins may be involved in senescence.

MeSH terms

Antigens, Polyomavirus Transforming / immunology
Cell Transformation, Viral / immunology
Cells, Cultured
Cellular Senescence / immunology*
Epitopes / immunology*
Humans
Precipitin Tests
Proteins / immunology
Tumor Suppressor Protein p53 / immunology*

Substances

Antigens, Polyomavirus Transforming
Epitopes
Proteins
Tumor Suppressor Protein p53