CD8+ cutaneous anaplastic large-cell lymphoma: report of two cases with immunophenotyping, T-cell-receptor gene rearrangement and electron microscopic studies

Br J Dermatol. 1992 Apr;126(4):404-8. doi: 10.1111/j.1365-2133.1992.tb00690.x.

Abstract

Two cases are reported of cutaneous anaplastic large-cell lymphoma with the suppressor/cytotoxic (CD8) phenotype. In both cases there was a solitary skin tumour in which there was a dense infiltrate with large irregularly shaped cells which on immunophenotyping expressed CD8. DNA hybridization analysis showed rearrangements of the T-cell-receptor gene in both cases.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, CD / analysis
  • Antigens, CD1
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Antigens, Neoplasm / analysis
  • CD3 Complex
  • CD8 Antigens / analysis*
  • Female
  • Gene Rearrangement, T-Lymphocyte / genetics
  • Humans
  • Immunophenotyping / methods
  • Keratins / analysis
  • Ki-1 Antigen
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Large B-Cell, Diffuse / immunology*
  • Lymphoma, Large B-Cell, Diffuse / pathology
  • Molecular Probe Techniques
  • Receptors, Antigen, T-Cell / analysis
  • Receptors, Antigen, T-Cell / genetics
  • Skin Neoplasms / genetics
  • Skin Neoplasms / immunology*
  • Skin Neoplasms / pathology

Substances

  • Antigens, CD
  • Antigens, CD1
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • CD3 Complex
  • CD8 Antigens
  • Ki-1 Antigen
  • Receptors, Antigen, T-Cell
  • Keratins