Effect of long-term treatment with somatostatin analogue (SMS 201-995) on pituitary tumor shrinkage in acromegaly--report of two cases

Neurol Med Chir (Tokyo). 1992 Apr;32(4):215-9. doi: 10.2176/nmc.32.215.

Abstract

The effect of long-term somatostatin analogue (SMS 201-995) treatment in two acromegalic patients is reported. Continuous tumor shrinkage was observed even after 129 and 139 weeks of treatment with 600 micrograms of SMS 201-995 daily. A huge and firm adenoma underwent shrinkage during treatment with SMS 201-995. No serious side effect appeared during 160 weeks of treatment. SMS 201-995 has a longterm tumor shrinkage effect and improves endocrinopathies.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acromegaly / drug therapy*
  • Acromegaly / etiology
  • Acromegaly / surgery
  • Adenoma / complications
  • Adenoma / diagnostic imaging
  • Adenoma / drug therapy*
  • Adenoma, Acidophil / complications
  • Adenoma, Acidophil / diagnostic imaging
  • Adenoma, Acidophil / drug therapy*
  • Adenoma, Acidophil / surgery
  • Adult
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Octreotide / therapeutic use*
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / diagnostic imaging
  • Pituitary Neoplasms / drug therapy*
  • Pituitary Neoplasms / surgery
  • Radiography

Substances

  • Octreotide