Abstract
Shiraiachrome-A and -B have been isolated from the mycelium of the Chinese bamboo fungus Shiraia bambusicola as the cytotoxic principles. A series of new perylene derivatives (7-27) related to Shiraiachrome-A and -B as well as Calphostin-C have been synthesized and evaluated for their cytotoxicity, antiviral activity, and inhibitory activity against protein kinase C. The results indicated that 11 and 12 are potent cytotoxic agents against HCT-8, RPMI-7951, and TE-671 solid tumor cells, whereas 24 and 26 demonstrated strong antiviral activity against HSV-1 and HSV-2. Compound 10 is an inhibitor of protein kinase C.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antiviral Agents / pharmacology*
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthalenes*
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Perylene / analogs & derivatives*
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Perylene / chemistry
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Perylene / pharmacology*
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Polycyclic Compounds / chemistry
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Polycyclic Compounds / pharmacology*
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Protein Kinase C / antagonists & inhibitors*
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Simplexvirus / drug effects
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Tumor Cells, Cultured
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Vero Cells
Substances
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Antineoplastic Agents
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Antiviral Agents
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Naphthalenes
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Polycyclic Compounds
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Shiraiachrome A
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Perylene
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Protein Kinase C
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calphostin C