Abstract
A PCR-based strategy for amplifying putative receptors involved in murine olfaction was employed to isolate a member (OR3) of the seven-transmembrane-domain receptor superfamily. During development, the first cells that express OR3 appear adjacent to the wall of the telencephalic vesicle at embryonic day 10. The OR3 receptor is uniquely expressed in a subset of olfactory cells that have a characteristic bilateral symmetry in the adult olfactory epithelium. This receptor and its specific pattern of expression may serve a functional role in odor coding or, alternatively, may play a role in the development of the olfactory system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antisense Elements (Genetics)
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DNA / genetics*
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DNA / isolation & purification
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Embryo, Mammalian
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Epithelial Cells
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Epithelium / physiology
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Genomic Library
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Olfactory Pathways / cytology
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Olfactory Pathways / physiology*
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Polymerase Chain Reaction / methods
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Protein Conformation
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RNA / genetics
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RNA / isolation & purification
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RNA, Antisense
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Receptors, Neurotransmitter / genetics*
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Receptors, Odorant*
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Restriction Mapping
Substances
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Antisense Elements (Genetics)
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RNA, Antisense
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RNA, Messenger
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Receptors, Neurotransmitter
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Receptors, Odorant
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G-protein coupled receptor OR3
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RNA
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DNA
Associated data
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GENBANK/M84005
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SWISSPROT/P23275