Abstract
A full-length cDNA for a rat type II activin receptor was cloned by hybridization from a rat ovary cDNA library. The deduced amino acid sequence (513 residues) containing a single membrane-spanning domain and an intracellular kinase domain with predicted serine/threonine specificity. The amino acid sequence is 99.8% and 99.4% identical in the coding region with the previously cloned mouse and human type II activin receptor, and only 66.7% identical in the coding region with the previously cloned rat type IIB activin receptor. We examined the effect of PMSG-hCG on the mRNA level of type II activin receptor in immature rat ovaries. Northern blot analysis of ovarian RNA revealed two mRNAs (3.0 kb and 6.0 kb).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Activin Receptors
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Amino Acid Sequence
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Animals
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Base Sequence
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Chorionic Gonadotropin / pharmacology
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Cloning, Molecular
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DNA / genetics
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DNA / isolation & purification
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Female
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Gonadotropins, Equine / pharmacology
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Humans
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Molecular Sequence Data
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Ovary / drug effects
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Ovary / physiology
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Poly A / genetics
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Protein Serine-Threonine Kinases / genetics*
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RNA / genetics
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RNA / isolation & purification
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RNA, Messenger
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Rats
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Rats, Wistar
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Receptors, Cell Surface / genetics*
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Sequence Homology, Amino Acid
Substances
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Chorionic Gonadotropin
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Gonadotropins, Equine
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RNA, Messenger
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Receptors, Cell Surface
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Poly A
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RNA
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DNA
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Protein Serine-Threonine Kinases
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Activin Receptors
Associated data
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GENBANK/S39996
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GENBANK/S40001
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GENBANK/S40008
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GENBANK/S40009
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GENBANK/S40010
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GENBANK/S48190
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GENBANK/X65120
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GENBANK/X72578
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GENBANK/X72579
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GENBANK/X72580