[Swiss Register for unrelated bone marrow donors: preliminary results]

Schweiz Med Wochenschr. 1992 Jul 25;122(30):1117-22.
[Article in German]

Abstract

Bone marrow transplantation from the unrelated volunteer donor is today a realistic possibility for patients lacking an HLA-identical family donor. In 1988, the Swiss Unrelated Bone Marrow Donor Registry was founded to coordinate such bone marrow transplants and create the Swiss volunteer donor registry. Thus for a search has been initiated for 71 patients and 16 transplants have been performed. Donor and recipient were HLA-A-, -B- identical by serology and HLA-Dr-identical by DNA-oligotyping. 10 of the 16 patients are alive without signs of basic disease 2 weeks to 2 years and 4 months after the transplant. These results illustrate that unrelated donor transplantation, using careful selection criteria, is a realistic new therapeutic modality.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Bone Marrow Transplantation* / mortality
  • Child
  • Child, Preschool
  • Female
  • HLA Antigens
  • Histocompatibility Testing / methods
  • Humans
  • Infant
  • Information Systems
  • Lymphocyte Culture Test, Mixed
  • Male
  • Registries*
  • Switzerland
  • Tissue Donors*

Substances

  • HLA Antigens