Effect of CD23 on purified human hematopoietic cells

D Mossalayi; A Dalloul; M Arock; P Debre

Effect of CD23 on purified human hematopoietic cells

Bone Marrow Transplant. 1992:9 Suppl 1:50-3.

Authors

D Mossalayi¹, A Dalloul, M Arock, P Debre

Affiliation

¹ Lab. Immunologie Cellulaire URA CNRS Pitie Salpetriere, France.

PMID: 1387018

Abstract

We report herein the effect of soluble CD23 (sCD23) on the differentiation of lymphoid and myeloid precursors. CD23 is known as the low affinity receptor for IgE. In addition to it, our results indicate that sCD23 in synergy with IL1 is able to promote the maturation of normal and leukemic hematopoietic progenitor cells.

Publication types

Review

MeSH terms

Antigens, Differentiation, B-Lymphocyte / physiology*
Bone Marrow / embryology
Bone Marrow Cells
Cell Differentiation / drug effects
Hematopoietic Stem Cells / drug effects*
Humans
Leukemia, Myeloid, Acute / pathology
Neoplastic Stem Cells / drug effects
Receptors, Fc / physiology*
Receptors, IgE
Solubility
T-Lymphocytes / cytology*
Thymus Gland / cytology
Thymus Gland / embryology
Tumor Cells, Cultured / drug effects

Substances

Antigens, Differentiation, B-Lymphocyte
Receptors, Fc
Receptors, IgE