8-Methoxypsoralen blocks ATP-sensitive potassium channels and stimulates insulin release

A Szewczyk; J R De Weille; M Lazdunski

doi:10.1016/0014-2999(92)90379-i

8-Methoxypsoralen blocks ATP-sensitive potassium channels and stimulates insulin release

Eur J Pharmacol. 1992 Jun 5;216(2):323-6. doi: 10.1016/0014-2999(92)90379-i.

Authors

A Szewczyk¹, J R De Weille, M Lazdunski

Affiliation

¹ Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.

PMID: 1397018
DOI: 10.1016/0014-2999(92)90379-i

Abstract

8-Methoxypsoralen (8-MOP) stimulated insulin release from HIT-T15 B-cells and inhibited the diazoxide-induced and sulfonylurea-sensitive 86Rb+ efflux from these cells. These results indicate that 8-MOP affects ATP-sensitive K+ channel activity. Patch-clamp experiments confirmed this view.

MeSH terms

Adenosine Triphosphate / pharmacology*
Animals
Guinea Pigs
Insulin / metabolism*
Insulinoma / metabolism
Islets of Langerhans / drug effects
Islets of Langerhans / metabolism
Methoxsalen / pharmacology*
Potassium Channels / drug effects*
Rubidium Radioisotopes
Tumor Cells, Cultured

Substances

Insulin
Potassium Channels
Rubidium Radioisotopes
Adenosine Triphosphate
Methoxsalen